Previous transcriptional profiling of gene expression changes induced by DUX4 constructs (GEO accession number GSE77100; http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE77100) has revealed that DUX4 in murine satellite cells recapitulates a transcriptional signature that has been identified in human FSHD muscle biopsies (Banerji et al., 2015a). Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.