CDKN2B and coronary artery disorder: The most frequently replicated locus is 9p21.3, which contains the long non-coding RNA, CDKN2B–AS1, and is adjacent to the cyclin-dependent kinase inhibitor genes, CDKN2A and CDKN2B. The same linkage block in 9p21.3 associated with IBA has also been associated with other vascular diseases, including coronary artery disease, myocardial infarction, and abdominal aortic aneurysms: this suggests that there may be a single locus that predisposes to all of these conditions via a common pathology (Helgadottir et al. 2008, 2007).