The secretion of immunomodulatory cytokines from GBM cells, including interleukins 10 (IL-10), 4 (IL-4) and 6 (IL-6), and particularly, tumour growth factor-beta (TGF-β) in addition to prostaglandin E2 [5] can supress microglia activation [6]. This evidence concerns the gene IL10 and glioblastoma.