The role of novel MIF family member MIF-2/D-DT is currently unclear, as its knockout in a mouse model led to an exacerbation of infarct size, while its levels in patients undergoing coronary artery bypass grafting are predictive of ischemia–reperfusion outcome parameters, such as acute kidney injury [92], clearly necessitating the application of additional models on this and to-be-discovered family members, as well as on the MIF/MIF-2 double knockout mouse. This evidence concerns the gene MIF and ischemia.