In the context of ischemic heart disease, TNF-α, a major player of the immune system, initiates the induction of a cardioprotective signaling pathway [89] that involves the activation of the signal transducer and activator of transcription 3 (STAT-3) [70], designated as the SAFE (“Survivor Activating Factor Enhancement”) pathway [50, 53]. This evidence concerns the gene STAT3 and coronary artery disorder.