ESR1 and triple-negative breast carcinoma: We did not find that rs4245739 was associated with the risk of cancer in Caucasians, although three GWAS studies [27, 37, 38] reported that this SNP increased the risk of ER-negative or triple negative breast cancer (defined by the absence of ER, progesterone receptor and human epidermal growth factor receptor-2) in the Caucasian population.