The following publications were excluded: four [31–34] in which the experimental designs were not case control studies; two publications [35, 36] that did not describe MDM4 polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) and cancer risk, three [37–39] that not provide detailed genotyping data, and two [28, 40] that might have described partially overlapping populations, so we included the study [28] with the larger sample size. This evidence concerns the gene MDM4 and cancer.