RARRES2 and cardiovascular disorder: Biased agonism is emerging as an important concept in GPCR research and has the potential to revolutionize how novel drugs for cardiovascular disease treatment are made.43, 44 In this study, we used chemerin(21–157) as our reference compound because it is found in human ascitic fluid9 and is reported to be the most active endogenous isoform of chemerin.1 We have identified that C‐terminal fragment, C9, previously reported to mimic the actions of chemerin,18 has a similar potency to chemerin in cAMP inhibition assays only, but is significantly less potent at activating β‐arrestin.