Circulating chemerin concentration positively correlates with both systolic and diastolic blood pressure in a range of patient populations, particularly those with obesity,48 metabolic syndrome,49, 50, 51, 52 type 2 diabetes mellitus,53, 54 and type 2 diabetes mellitus with hypertension,7 and these patient groups are at higher risk of developing cardiovascular disease. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.