BRCA1 and breast cancer: Two other identified variants that call our attention were: (i) the c.5096G>A (BRCA1), identified in a family without BC history (proband with OC at 44 and one relative with OC), which was the only variant identified in families with cancer history exclusive of OC and (ii) the in frame deletion c.5425_5430delGTTGTG, due to the severity of the family history (proband with BC at 36 years old and 7 cases of BC among first, second and third degree relatives).