BRCA1 and breast cancer: Among the 349 probands, 21.5% were germline mutated (n = 75) with 65.3% of them carrying mutations in BRCA1 and 34.7% in the BRCA2. When segregating mutated patients according to primary tumor site, 20.5% of patients with BC were mutated (60 cases) being 63.3% of the mutations in the BRCA1 gene and 36.7% in BRCA2. Among patients whose primary tumor was OC, 30.0% (15 patients) presented pathogenic mutations in the BRCA1/BRCA2 genes, with the majority (73.3%) being located in BRCA1.