This is the case, for example for the age at diagnosis and the number of BC seen in the families carrying the alterations c.5425_5430delGTTGTG (BRCA1), c.6347A>G (BRCA2) and c.1601A>G (BRCA1) (8, 5 and 6 BC cases respectively), as well as the very early ages at diagnosis (24 years old) of the probands with the variants c.5096A>G (BRCA2) and c.6988A>G (BRCA2). The gene discussed is BRCA2; the disease is breast cancer.