To identify the effect of SENP1 on glycolysis in ccRCC, the mRNA expression levels of the key glycolytic enzymes, including PGK1, PFK1, ENO1, ALDOA, CA9, LDHA, and HK2, in ccRCC tumor and adjacent normal tissues were examined by real-time RT-PCR. The gene discussed is ENO1; the disease is nonpapillary renal cell carcinoma.