Furthermore, in ccRCC patients with clinical TNM stage I–III after radical nephrectomy, SENP1 expression correlated with tumor progression, and patients with high SENP1 expression were more likely to suffer disease progression (P = 0.039, Figure 4D), and markedly shorter time to disease progression (P < 0.001, Figure 4E). Here, SENP1 is linked to nonpapillary renal cell carcinoma.