We then compared the differences in frequency distributions of alleles between cases and controls using Chi-squared tests and found that the frequency of allele “G” of rs10757274 in CDKN2BAS was higher in cases, and it was associated with a 1.30-fold increased risk of CHD in men at a 5% level (OR = 1.30, 95% CI: 1.05-1.61, P = 0.018). The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.