SPARC and myelodysplastic syndrome: Some of these submicroscopic CNAs involved regions with genes of known significance in MDS pathogenesis and were deletions in 2p23.3 (DNMT3A), 4q24 (TET2), 5q33.1 (SPARC), 7q22.1 (CUX1), 21q22.12 (RUNX1) and Xp11.4 (BCOR), and gains in 21q22.3 (U2AF1), that were detected in 19 patients [18,25,26,30].