Notably, these cryptic CNAs involved regions such as 2p23.3, 4q24, 5q33.1, 7q22.1, 21q22.12, 21q22.3 and Xp14, where genes implicated in the pathogenesis of MDS and MDS/MPN are located, including DNMT3A, TET2, SPARC, CUX1, RUNX1, U2AF1 and BCOR, respectively (Fig 2B). This evidence concerns the gene CUX1 and myelodysplastic syndrome.