Currently, it is believed that Kimura disease is due toy type I hypersensitivity reaction or T cell-associated immune disorder.[25] Some investigators showed that elevated CD4+ T cells and CD4+/CD8+ ratio in Kimura disease.[26] Eosinophilia and IgE elevations suggest hyperfunctioning of Th2 cells. The gene discussed is IGHE; the disease is Increased total eosinophil count.