Renal biopsy revealed membranous nephropathy (Fig. 1A), immunofluorescence microscopy showed the presence of HbsAg (++) and HBcAg (++) and deposition of IgA (+++), IgG (++++), IgM (+++), C3 (++++), C4 (++), and C1q (+++) in the capillary loops and mesangium (Fig. 1B−H). The gene discussed is CD40LG; the disease is membranous glomerulonephritis.