CD4 and systemic lupus erythematosus: SLE patients also have abnormality in lymphocyte subset distribution, and recent evidence suggests that patients with active SLE have reduced CD4+ T cells and CD4+/CD8+ ratio, while the number of CD8+ cells remained unchanged or elevated.[28,29] We determined T cell subsets of the patient during the active and remission stage of SLE and found that the number of CD4+ T cells and CD4+/CD8+ ratio were decreased while CD8+ cells increased, which is different from previous report on Kimura disease, but consistent with SLE.