OxLDL (< 5 μg/ml) has been shown to stimulate endothelial lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)/mitogen-activated protein kinases (MAPK)/NF-kB signaling pathway to induce cytokines, metalloproteinases, vascular endothelial growth factor (VEGF), peroxisome proliferator-activated receptor-gamma (PPAR-γ) and LOX-1 expression, thus involve in the progression of angiogenesis/atherosclerosis/carcinogenesis [10]. The gene discussed is VEGFA; the disease is atherosclerosis.