PARP1 and Friedreich ataxia: PARP is involved in the repair of DNA single-strand breaks (SSBs), and when it is inhibited, DNA SSBs degenerate to more lethal DNA double-strand breaks (DSBs) that require repair by homologous recombination (HR), which requires the activation of the Fanconi Anemia (FA)/BRCA pathway, a DNA-damage response signaling pathway which is essential for the repair of DNA interstrand cross-links induced by DNA-damaging agents [9-11].