The previously mentioned cSRY decoys miR-138, for which it displays 16 target sites.12, 24 Circ-ITCH, a circRNA downregulated in carcinomas, was demonstrated to be a sponge of miR-7, miR-17 and miR-214, by increasing the level of ITCH and ultimately inhibiting the Wnt/β-catenin pathway.58, 59 Another circRNA (hsa_circ_001569) that acts as a sponge for miR-145 upregulates its targets enhancing cell proliferation and invasion of colorectal cancer.60 This evidence concerns the gene ITCH and colorectal cancer.