Pygosus 2 (PYGO2) is a component of the Wnt signaling pathway required for β-catenin/T-cell factor (TCF)-dependent transcription and has been shown to be upregulated in lung cancer both in vitro in non-small cell lung cancer cell lines and in vivo in human primary tumor tissue samples (Zhou et al. 2014). This evidence concerns the gene PYGO2 and lung cancer.