APEH and myalgic encephalomeyelitis/chronic fatigue syndrome: Noteworthy, data in Figure 3E and F revealed that p21 depletion caused the accumulation of the FRA7H CFS instability to an extent similar to that caused by low doses of APH, a known inducer of CFS instability (Bergoglio et al., 2013; Sutherland et al., 1985).