The leptin/LepRb signaling was tested subsequently to identify the levels of plasma leptin and expression of protein and mRNA of LepRb in the hippocampus and hypothalamus and their relationship with weight gain, depression/anxiety-like behavior and cognitive impairment in rats that were exposed to HFD and CUMS, CUMS only, HFD only and the control group. The gene discussed is LEP; the disease is Cognitive impairment.