The G allele of CCL2 rs1024611, which is known to be a risk allele for inflammatory infective and non-infective diseases28, 29, could simultaneously participate in progressing chronic kidney disease in nephrolithiasis patients as indicated by the interaction of CCL2 rs1024611 with CASR rs7652589 in the studied HD subjects. This evidence concerns the gene CASR and nephrolithiasis.