Considering the regulatory role of EGFR-PI3K-Akt signalling to activate SREBP-148, 50 and the inherent function of SREBP-1 to regulate lipid metabolism39, 40, it will be interesting to examine its association with the increase of PUFAs and phospholipids in NSCLC patients, particularly those observed in EGFR mutants in subsequent studies. Here, SREBF1 is linked to non-small cell lung carcinoma.