The former includes a large class of growth factors or cytokines such as Vascular endothelial growth factor (VEGF), Basic Fibroblast Growth Factor (bFGF), angiopoietin, Matrix metalloproteinases (MMPs), interleukin-1 (IL-1), IL-8, and the latter includes endostain, angiostain, Tissue inhibitor of matrix metalloproteinases (TIMPs), etc. ARTs can inhibit the formation of tumor blood vessels by downregulating the production of growth factors as well as upregulating the inhibitory factors [62]. This evidence concerns the gene VEGFA and neoplasm.