TNF and rheumatoid arthritis: Over the last few years, increasing evidence was found demonstrating there is no increased risk of most cancers for RA patients on tumor necrosis factor (TNF)-inhibitor therapy compared with conventional disease-modifying anti-rheumatic drug (DMARD) therapy such as methotrexate or leflunomide, and that the risk of cancer did not increase over time for patients on TNF inhibitor therapy [12].