Moreover, further multivariate logistic regression analyses revealed that both plasma CTRP-3 and HMGB-1 concentrations were significantly correlated with pre-DM and nT2DM after controlling for several covariates including age, gender, BMI, WHR, blood pressure, TC, TG, LDL-C, HDL-C, and liver and kidney function (P < 0.001 for all) (Tables 3 and 4). Here, HMGB1 is linked to diabetes mellitus.