Compared with the NGT group (486.548 ± 37.09, ng/mL), subjects displayed a decreased trend of plasma CTRP-3 concentrations in pre-DM (419.649 ± 46.34, ng/mL) and nT2DM group (356.107 ± 49.5, ng/mL) (Figure 1(a), P for trend < 0.001). The gene discussed is C1QTNF3; the disease is diabetes mellitus.