SOCS1 and experimental autoimmune encephalomyelitis: In vivo SOCS1 overexpression in oligodendrocytes suppresses deleterious actions observed in experimental autoimmune encephalomyelitis, as well as attenuating SOCS1 expression in microglia-promoted proinflammatory M1-like microglia and worsening neuroinflammation [52], suggesting that SOCS1 plays a crucial role in modulating cytokine responses and might be a promising therapeutic modulator in CNS disease states.