In contrast, IL-17A and IFN-γ were significantly amplified in SLE; mainly IL-17A acts as a powerful predictor cytokine because it was markedly correlated with disease activity and associated with more pyuria and proteinuria, whilst the serum level of IFN-γ was associated with more pyuria and hematuria [28]. The gene discussed is IFNG; the disease is systemic lupus erythematosus.