CYLD and lung cancer: As shown in Figures 2(c) and 2(d), the cell viability was significantly increased in CYLD-knockdown A549 cells and H460 cells compared to that in N.C. siRNA-transfected cells after transfection for 48 hours and 72 hours (∗p < 0.01, ∗∗p < 0.05, compared with N.C. siRNA-transfected cells) suggesting knockdown CYLD in lung cancer cells obviously promoted cell proliferation of A549 and H460 cells.