HSPG2 and neoplasm: In conclusion, similarly to other tumor models, the large amount of PLC-CTC studies allow the definition of key findings such as correlation with patients’ clinical and pathological data (tumor grade, TNM stage, recurrence, etc.)and treatment response, CTC-prognostic significance, CTC-heterogeneity as well as the inadequacy of EpCAM as only marker CTC-isolation and necessity to improve CTC-detection methods [53, 54, 108, 109, 112, 113, 115, 128, 131–138].