More interestingly only those putative PLC stem-like subpopulation capable to initiate tumor development at low cell numbers, were further tested for ‘self-renewal’ capacity in serial tumor transplantations and molecularly for presence of hepatic stemness-related pathways (e.g. developmental signaling and transcription factors, epigenetic regulation including specific miRNAs) [23, 62, 64–94] (Table 2 and reviewed in [47]). The gene discussed is HSPG2; the disease is neoplasm.