PTPRC and hepatocellular carcinoma: Xu et al. measured CTCs in blood samples from 85 HCC patients at various stages and defined them as cell with larger cell size, intact nuclei, high nucleus-to-cytoplasm ratio, CD45- (leukocytes marker) and HepPar1+ (a hepatocyte-specific marker, which binds mitochondria antigens present in liver-derived cells).