Vincenzo Ficarra et al. and Muneer, A. et al. reviewed the reported data concerning the prognostic markers in patients with penile squamous cell carcinoma (SCC) including tumor histologic grade, tumor histologic subtype, tumor pathologic extension and lymphatic and/or venous embolization, metastasis in regional lymph nodes, tumor growth pattern, p53, E-cadherin, MMP-2, and MMP-9 [5, 6]. This evidence concerns the gene MMP9 and neoplasm.