Among others from this series, tTF-NGR (HIStag-tTF1-218-GNGRAHA) as a model fusion protein retains its procoagulatory activity in vitro, binds to the respective targets on endothelial and tumor cells, and upon intravenous infusion induces vascular infarction in blood vessels of human tumors of various histologies growing in athymic mice with subsequent tumor growth retardation or regression. The gene discussed is RTN4R; the disease is neoplasm.