As shown by FX activation kinetics, HUVEC and HT1080 or M21 tumor cells showed a significantly higher procoagulatory efficacy when used with equimolar concentrations of tTF-NGR upon doxorubicin incubation and higher PS externalization than identical numbers of control cells with low PS externalization (Figures 5C, 6C, and 7C). This evidence concerns the gene RHOH and neoplasm.