As shown by FX activation kinetics, HUVEC and HT1080 or M21 tumor cells showed a significantly higher procoagulatory efficacy when used with equimolar concentrations of tTF-NGR upon doxorubicin incubation and higher PS externalization than identical numbers of control cells with low PS externalization (Figures 5C, 6C, and 7C). The gene discussed is RTN4R; the disease is neoplasm.