NOTCH1 and colorectal carcinoma: In this study, we used oxaliplatin (L-OHP; a platinum anticancer drug for the treatment of CRC) and vincristine (VCR; a broad-spectrum anticancer drug) to establish a drug-resistant cell model, and explored the involvement of CSCs, miR-139-5p, and its potential target (NOTCH1) in CRC drug resistance.