Of the 53 differentially methylated candidates that were found in both ADC and SCC, 20 genes (Supplementary Table S3) were described previously in literature as being more frequently methylated in cancer, and 6 genes in (squamous-cell) cervical cancer (SOX1, SOX14, ONECUT1 and WT1) [44] or high-grade CIN (GFRA1, SOX1 and TBX20) [34, 45]. Here, GFRA1 is linked to cervical squamous intraepithelial neoplasia.