Recently, PAX1, PTPRR, SOX1 and ZNF582, previously reported to be frequently methylated in scrapings of SCC patients, were also analyzed in scrapings of ADC patients and showed a sensitivity of the single genes of 82% - 93% with a specificity of 81% - 95% in a Taiwanese population [26]. The gene discussed is ZNF582; the disease is AIDS dementia complex.