SAV1 and pachyonychia congenita: Moreover, miR-181c directly repressed MST1 (mammalian STE20-like protein kinase 1), LATS2 (large tumor suppressor 2), MOB1 (MOB kinase activator 1) and SAV1 (Salvador homologue 1), leading to YAP/TAZ activation and subsequent promotion of PC cell survival and chemoresistance both in vitro and in vivo [34].