SPP1 and breast carcinoma: AntimiR-218-5p diminished the expression of several genes associated with bone metastasis and osteoclast activation, including osteopontin (OPN/SPP1), bone sialoprotein (BSP/IBSP), CXCR4, and PTHrP/PTHLH (Supplementary Figure S6B), suggesting that antimiR-218-5p suppresses the osteomimetic properties of metastatic breast cancer cells.