In the same perspective, mutations in the V-Ki-ras2 Kirsten rat sarcoma viral oncogne homologue (KRAS), epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homologue B1 (BRAF) and translocations of the anaplastic lymphoma kinase (ALK) gene locus have been found in several lung adenocarcinoma (ADC) with important implications for targeted therapies [20,112]. The gene discussed is ALK; the disease is lung adenocarcinoma.