However, in contrast to normal cells (see Fig 1B), Am80‐GCSF induced significantly higher expression of RA‐target genes than did GCSF in AML cells throughout the full differentiation induction period (Fig 2Bi, days 2, 3, 6), including tumor suppressor RARβ2 (Soprano et al, 2004; Alvarez et al, 2007), terminal granulocytic differentiation regulator C/EBPε (Park et al, 1999; Lekstrom‐Himes, 2001), and CR3 component CD11b (Park et al, 1999). Here, CRIPTO3 is linked to acute myeloid leukemia.