Although Am80 is selective for RARα and RARβ, which function as the master regulators of granulocytic differentiation and tumor suppression, respectively (Alvarez et al, 2007; Collins, 2008), it preferentially activates RARα (Umemiya et al, 1997; Kagechika, 2002; Jimi et al, 2007). This evidence concerns the gene RARA and neoplasm.