Reverse genetic mutations in the CC/TZ protein CC2D2A (Bachmann-Gagescu et al., 2011), axoneme protein RP2 (Liu et al., 2015), and myosin 7A (Wasfy et al., 2014) result in photoreceptor degeneration in zebrafish, indicating that zebrafish are an excellent model for the study of photoreceptor diseases associated with ciliopathies. The gene discussed is CC2D2A; the disease is ciliopathy.