In mouse photoreceptors, several protein complexes involved in Usher syndromes, a group of genetic diseases that exhibit photoreceptor degeneration, are localized at or near the CC/TZ including Usher 1 syndrome (USH1) proteins (Reiners et al., 2006), USH2 proteins (Chen et al., 2014; Ebermann et al., 2007; Eudy et al., 1998; Liu et al., 2007; Mburu et al., 2003; Wang et al., 2012; Weston et al., 2004), and the USH3 protein clarin-1 (Zallocchi et al., 2009). Here, CLRN1 is linked to hereditary disease.