Previous studies have revealed aberrant expressions of PD-1/PD-L1 in NKTCL cell lines and tissues as well as involvement of PD-1/PD-L1 in the downregulation of antitumor immunity, suggesting that PD-1/PD-L1 may serve as a potential candidate for immunotherapy in NKTCL [28]. The gene discussed is CD274; the disease is extranodal nasal NK/T cell lymphoma.