Next, we examined the effect of MAPK or NF-κB signaling on cleavage of N-cadherin.PMA-treated NPC cells with an ERK1/2, p38 or NF-κB inhibitor incubation showed no accumulation of CTF1/N-cad induced by γI (Fig. 5c). Here, CDH2 is linked to nasopharyngeal carcinoma.