Strikingly, five days post-infection, we found a significant defect in the percentage of TNF and IL-6 positive Ripk3-/-Casp8-/- inflammatory monocytes isolated from the mesenteric lymph nodes (mLN) of mixed BM chimeras compared with either wild-type or Ripk3-/- cells from the same animal (Fig 1B and 1C and S1B and S1C Fig). Here, CASP8 is linked to infection.