We also found a VGF C-terminus reduction in fibroblasts (Fig 1B) obtained from ALS patients at the advanced stage, with either TDP-43 mutation or unidentified aetiology (percentage decrease: 47% p<0.04; 51%, p<0.02, respectively), compared to the control cells Raw data from ELISA are reported in S2 Dataset. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.