In conclusion, In addition to traditional biomarkers, the current cross-sectional study details new biochemical features of lipoproteins from RA patients; increased CETP mass and activity, elevated TG content and glycation extent in blood and lipoproteins, lowered antioxidant activity, and multimerization of apoA-I can be useful biomarkers of RA. Here, APOA1 is linked to rheumatoid arthritis.