We, and others, reported that recombinant angptl2 significantly reduced acetylcholine-induced dilation of isolated mouse arteries and, conversely, that angptl2 knockdown or knockout mice were protected against endothelial dysfunction induced by a high-fat diet [18, 27] and chronic infusion of low dose angiotensin II [41]. Here, ANGPTL2 is linked to endothelial dysfunction.