In their comprehensive analysis of vitamin D-related genes in 749 incident prostate cancer cases and 781 controls, Ahn and colleagues reported positive associations between VDR tag SNPs in or near the 3′ region and prostate cancer risk among men with low vitamin D, but not with high vitamin D. In particular, this association was stronger for VDR variant rs11574143 [22]. Here, VDR is linked to Familial prostate cancer.