In contrast, Tg-Sub-III-CAST/FVB and Tg-Sub-IVCAST/FVB mice showed a 1.5–2.4 fold increase in glomerulosclerosis, tubule-interstitial casts/cysts, tubular atrophy/interstitial fibrosis and inflammation (Table 1 and Fig 2), and were comparable to the TgFVB-HIVAN1CAST strain mice carrying the full congenic segment. The gene discussed is CAST; the disease is glomerulosclerosis.