In the present study, we have found no functional deficits in both female and male tauGFP/GFP or tauGFP/+ mice at 16 months of age, when compared to their tau+/+ littermates; this included motor (Rota-Rod, Hanging Wire), spatial memory (MWM), locomotor (OF) and anxiety/disinhibition behavior (EPM) testing. Here, MAPT is linked to Anxiety.