Reduced ALDH2 activity was correlated with mitochondrial respiratory dysfunction {mitochondrial reserve capacity (Fig 5A) and maximal respiration (Fig 5B)}, pathological cardiac remodeling {cardiac hypertrophy (Fig 5C) and fibrosis (Fig 5D)} and cardiac dysfunction {%FS (Fig 5E) and end-diastolic pressure (Fig 5F)}. The gene discussed is ALDH2; the disease is cardiac hypertrophy.