Similarly, the correlation of different combinations of CD68+ macrophages infiltrating between tumor nest and stroma with OS suggested that, patients with low infiltrating density of CD68+ macrophages in tumor nest and high infiltration density in tumor stroma had a best OS, while high or low infiltration in the both tumor nest and stroma displayed medium OS, and the patients with high infiltrating density of CD68+ macrophages in tumor nest and low infiltrating density in tumor stroma had a worst OS (median OS: 5.40, 1.60, 1.60 and 1.20 years, P = 0.0136). Here, CD68 is linked to neoplasm.