CHL1 and renal cell carcinoma: However, miR-590-5p was found to be upregulated in the examined renal cell carcinoma cell lines and seem to function as an oncomir by targeting PBRM1,18 whereas miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation.19 In the current study, we found that compared with non-metastatic and normal samples, miR-590-5p expression was downregulated in CRC specimens and CRC cell lines.