On the one hand, miR-590-5p was downregulated in breast cancer samples and could inhibit its metastasis,23 it was found that miR-590-5p levels in hepatocellular carcinoma (HCC) patients were inversely associated with tumor size, stage, epithelial–mesenchymal transition (EMT), and metastasis by targeting S100A1,24 which suggests its negative role in tumor development. This evidence concerns the gene S100A1 and breast carcinoma.