KRAS and colorectal carcinoma: For example, it has been shown that levels of miR-143 and miR-145 tend to be lower in CRC tissue than in normal tissue.10 Moreover, it was also reported that miR-143 and miR-145 function as tumor suppressors through the repression of KRAS translation in human CRC.10 These findings suggest a close relationship between miRNAs and the development of CRC.