Accumulating evidence established that miRNAs functions as effective molecular biomarkers for cancer diagnosis, prognosis, and therapy.25 miRNA-CHIP assays has indicated that many miRNAs were aberrantly expressed in CRC.26 Several steps were involved in the biogenesis of miRNAs.27 First, pri-miRNAs are transcribed from miRNA genes by RNA polymerase II. The gene discussed is STUB1; the disease is cancer.