Lin28A/B enhances the growth of breast and colon tumors via inhibition of let-7 miRNA biogenesis.30 These reports strongly support our current data: we indicated that NF90 induces CRC angiogenesis, growth, and metastasis through suppression of pri-miR-590 processing by binding of NF90 to pri-miR-590, thus decreasing the levels of mature miR-590-5p. The gene discussed is ILF3; the disease is colonic neoplasm.