Compared with the control, scrambled siRNA, VEGFA siRNA markedly inhibited neovascularization in CAM and HUVEC tube formation by the CM from miR-590-5p-deleted CRC cells (Figures 3c and d), thus supporting our suggestion that the high levels of angiogenesis induced by miR-590-5p knockdown were dependent on the elevated VEGFA levels. The gene discussed is VEGFA; the disease is colorectal carcinoma.