In addition, it is involved in regulating protein translation, DNA repair, RNA processing, host resistance to viral infections, and mitosis.16 Recently, NF90 was found to affect breast cancer angiogenesis and NF90/NF45 complex also mediates E6 oncogene expression in human papilloma virus-transformed cervical carcinoma cells.17 However, little is known about its role and regulation in CRC. This evidence concerns the gene ILF3 and breast cancer.