On the one hand, miR-590-5p was downregulated in breast cancer samples and could inhibit its metastasis,23 it was found that miR-590-5p levels in hepatocellular carcinoma (HCC) patients were inversely associated with tumor size, stage, epithelial–mesenchymal transition (EMT), and metastasis by targeting S100A1,24 which suggests its negative role in tumor development. The gene discussed is S100A1; the disease is hepatocellular carcinoma.