NF90 was known to enhance VEGFA expression, thereby promoting cancer growth and metastasis.21 To demonstrate if NF90 was a direct target of miR-590-5p in CRC cells, we conducted luciferase reporter assays after transfection of wild-type (wt) and mutated NF90 3′-UTR into CRC cells with synthetic miR-590-5p mimic. The gene discussed is ILF3; the disease is cancer.