These findings go in line with published data showing that blood C3 levels are higher in obese and diabetic patients, possibly contributing to the development of low-grade inflammation and insulin resistance,28 as it is known that obesity-linked inflammation mediates insulin resistance.40 Several studies have shown that increased blood C3 levels are associated with the level of obesity, being considered a risk factor to the development of diabetes and cardiovascular diseases.27 The gene discussed is C3; the disease is obesity due to melanocortin 4 receptor deficiency.