FOS and colorectal carcinoma: As shown in Figure 7, the level of CDK5 expression in 9 freshly collected clinical CRC samples significantly correlated with the phosphorylation level of ERK5 at Thr732 (r=0.683 P=0.042), c-jun (r=0.732 P=0.025) and c-fos (r=0.867 P=0.002).