To study the effect of TRAIL on adipogenic differentiation, we used human Simpson-Golabi-Behmel syndrome (SGBS) cells,21 which express both TRAIL-R1 and TRAIL-R2, but show a very low sensitivity to TRAIL-induced apoptosis.15, 17, 18. The gene discussed is TNFSF10; the disease is Simpson-Golabi-Behmel syndrome.